Product Name :Phospho-PKC (Ser660) Recombinant Rabbit mAb (KU)
Swiss-Prot :P17252,P05771,P05771-2,Q05655,Q02156,P24723,Q04759
Reactivity :Human, Mouse, Rat
Application_all :WB: 1:2000-1:10000<br />IHC: 1:50
Background :Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes. [provided by RefSeq, Jul 2008]
Product :Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Purification&Purity :Affinity Purification
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :AAG6; PKCA; PRKACA; PKCI+/-; PKCalpha; PKC-alpha
Immunogen :A synthetic phosphopeptide corresponding to residues surrounding Ser660 of human PKC
Modification :Phosphorylated
