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Parkin (phospho-S131) polyclonal antibody（KU）

货号: BS4341

价格：￥ 1350

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS4341

Product Name :Parkin (phospho-S131) polyclonal antibody（KU）

Swiss-Prot :O60260

Host :Rabbit

Reactivity :Human

Applications :WB

Application_all :WB: 1:500~1:1000

Background :Parkin is a zinc-finger protein that is related to ubiquitin at the amino terminus. The wild type Parkin gene, which maps to human chromosome 6q25.2- 27, encodes a 465 amino acid full-length protein that is expressed as multiple isoforms ranging from 50-58 kDa. Mutations in the Parkin gene are responsible for utosomal recessive juvenile Parkinson’s disease and commonly involve deletions of exons 3-5. In humans, Parkin is expressed in a subset of cells of the basal ganglia, midbrain, cerebellum and cerebral cortex, and is subject to alternative splicing in different tissues. Parkin expression is also high in the brainstem of mice, with the majority of immunopositive cells being neurons. The Parkin gene has been identified in a diverse group of organisms including mammals, birds, frog and fruit flies, suggesting that analogous functional roles of the Parkin protein may have been highly conserved during the course of evolution

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Parkin (phospho-S131) polyclonal antibody detects endogenous levels of Parkin protein only when phosphorylated at Ser131.

BiowMW :~ 52 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Dopamine Signaling in Parkinson's Disease Plathway,

Alternative Name :E3 ubiquitin-protein ligase parkin; Parkinson juvenile disease protein 2; Parkinson disease protein 2; PARK2; PRKN

Immunogen :Synthetic peptide derived from human Parkin around the phosphorylation site of S131.

Conjugate :Unconjugated

Modification :Phosphorylated

Western blot (WB) analysis of p-Parkin (S131) pAb at 1:500 dilution Lane1:MCF-7 whole cell lysate(40ug) Lane2:HCT116 whole cell lysate(40ug) Lane3:SGC7901 whole cell lysate(40ug)