Product Name :Phospho-SHP2 (Tyr542) Recombinant Rabbit mAb (KU)
Applications :WB,ICC/IF,IP
Application_all :WB: 1/500-1/1000 IF: 1/50-1/200 IP: 1/20
Background :The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. [provided by RefSeq, Aug 2016]
Product :Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification&Purity :Affinity Purified
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
BiowMW :Calculated MW: 124 kDa; Observed MW: 124 kDa
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :VCL; Vinculin; Metavinculin
Immunogen :A synthesized peptide derived from human Vinculin
