Product Name :Phospho-Rb (Thr826) Recombinant Rabbit mAb (KU)
Applications :WB,ICC/IF,IP
Application_all :WB: 1/500-1/1000 IF: 1/50-1/200 IP: 1/20
Background :The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq, Jul 2008]
Product :Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification&Purity :Affinity Purified
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
BiowMW :Calculated MW: 124 kDa; Observed MW: 124 kDa
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :VCL; Vinculin; Metavinculin
Immunogen :A synthesized peptide derived from human Vinculin
