Product Name :Phospho-ZAP70 (Tyr292) Recombinant Rabbit mAb (KU)
Applications :WB,ICC/IF,FC
Application_all :WB: 1:1000<br />ICC/IF: 1:100<br />FC: 1:20
Background :This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Product :Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Purification&Purity :Affinity Purification
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :SRK; STD; TZK; STCD; IMD48; ADMIO2; ZAP-70
Immunogen :A synthetic phosphopeptide corresponding to residues surrounding
Tyr292 of human ZAP70
Modification :Phosphorylated
