Product Name :Phospho-MLKL (Ser345) Recombinant Rabbit mAb (KU)
Application_all :WB,1:500 - 1:2000|IP,1:50 - 1:200
Background :This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to lack protein kinase activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (Rip3), which is a key signaling molecule in necroptosis pathway. Knockout of this gene in mice showed that it is essential for necroptosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2015]
Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Polyclonal Antibodies
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :NLRX1;CLR11.3;DLNB26;NOD26;NOD5;NOD9
Immunogen :Recombinant fusion protein of human NLRX1(NP_001269073.1).
Modification :Unmodification
