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Phospho-Rad17 (Ser656) Recombinant Rabbit mAb (KU)

货号: BS43121

价格：￥ 1200

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS43121

Product Name :Phospho-Rad17 (Ser656) Recombinant Rabbit mAb (KU)

Swiss-Prot :O75943

Host :Rabbit

Reactivity :Human

Applications :WB,IHC,ICC/IF

Application_all :WB: 1:1000-1:5000<br />IHC: 1:501:50

Background :The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Multiple alternatively spliced transcript variants of this gene, which encode four distinct protein isoforms, have been reported. Two pseudogenes, located on chromosomes 7 and 13, have been identified. [provided by RefSeq, Jul 2013]

Product :Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Purification&Purity :Affinity Purification

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IgG

BiowMW :80 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :CCYC; R24L; RAD24; HRAD17; RAD17SP

Immunogen :A synthetic phosphopeptide corresponding to residues surrounding Ser656 of human Rad17

Conjugate :Unconjugated

Modification :Phosphorylated

Western blot detection of Rad17 (phospho-Ser656) in Hela,Ramos using Rad17 (phospho-Ser656) antibody(1:1000 diluted)

免疫沉淀（IP）

免疫组织化学（IHC）