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Phospho-PML Protein (Ser518) Recombinant Rabbit mAb (KU)

货号: BS43094

价格：￥ 1200

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS43094

Product Name :Phospho-PML Protein (Ser518) Recombinant Rabbit mAb (KU)

Swiss-Prot :P29590

Host :Rabbit

Reactivity :Human, Mouse

Applications :WB,IHC

Application_all :WB: 1:1000<br />IHC: 1:50

Background :The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Product :Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Purification&Purity :Affinity Purification

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IgG

BiowMW :98,117 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :MYL; RNF71; PP8675; TRIM19

Immunogen :A synthetic phosphopeptide corresponding to residues surrounding Ser518 of human PML Protein

Conjugate :Unconjugated

Modification :Phosphorylated

Western blot detection of PML Protein (phospho-Ser518) in A549,HL-60,U2OS cell lysates using PML Protein (phospho-Ser518) antibody(1:1000 diluted).

免疫沉淀（IP）

免疫组织化学（IHC）