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Phospho-Presenilin 1 (Ser310) Recombinant Rabbit mAb (KU)

货号: BS43088

价格：￥ 1200

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS43088

Product Name :Phospho-Presenilin 1 (Ser310) Recombinant Rabbit mAb (KU)

Swiss-Prot :P49768

Host :Rabbit

Reactivity :Human

Applications :WB,ICC/IF

Application_all :WB: 1:2000<br />ICC/IF: 1:50

Background :Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq, Aug 2008]

Product :Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Purification&Purity :Affinity Purification

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IgG

BiowMW :22 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :AD3; FAD; PS1; PS-1; S182

Immunogen :A synthetic phosphopeptide corresponding to residues surrounding Ser310 of human Presenilin 1

Conjugate :Unconjugated

Modification :Phosphorylated

Western blot detection of Phospho-Presenilin 1/PS-1 (Ser310) in Jurkat,Hela cell lysates using Phospho-Presenilin 1/PS-1 (Ser310) antibody(1:1000 diluted).