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TBC1D4 (phospho-T642) polyclonal antibody（KU）

货号: BS4293

价格：￥ 1350

货期：现货（1-2个工作日）

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详细信息检测数据实验指南文献

No. :BS4293

Product Name :TBC1D4 (phospho-T642) polyclonal antibody（KU）

Swiss-Prot :O60343

Host :Rabbit

Reactivity :Human,Rat

Applications :WB IHC IF

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200

Background :TBC1 domain family member 4 (TBC1D4), also designated AS160, can be insulin- and/or AKT1-induced. Insulin-stimulated phosphorylation is required for GLUT4 translocation. TBC1D4 may play a role as a GTPase activating protein for proteins in the Rab family. It is expressed primarily in skeletal muscle and heart, as well as spleen, lymph node and leukocytes. Defects in the TBC1D4 gene may cause atopic dermatitis (AD), sometimes referred to as eczema, an atopic chronic skin disease. The skin of affected individuals reacts to irritants or allergens and becomes red, flaky and itchy. The skin is also more vulnerable to inflammations, and symptoms can grow or disappear over time.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :p-TBC1D4 (T642) polyclonal antibody detects endogenous levels of TBC1D4 only when phosphorylated at Thr642.

BiowMW :~ 160 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Insulin &Glucose Signaling,

Alternative Name :TBC1 domain family member 4; Akt substrate of 160 kDa; TBC1D4; AS160; KIAA0603

Immunogen :Synthetic phosphopeptide derived from human TBC1D4 around the phosphorylation site of Threonine 642.

Conjugate :Unconjugated

Modification :Phosphorylation

Western blot (WB) analysis of p-TBC1D4 (T642) pAb at 1:500 dilution Lane1:PC12 whole cell lysate(40ug) Lane2:HCT116 whole cell lysate(40ug) Lane3:SGC7901 whole cell lysate(40ug) Lane4:Panc1 whole cell lysate(40ug) Lane5:MCF-7 whole cell lysate(40ug) Lane6:HEK293T whole cell lysate(40ug)

Human Mesenchymal Stem Cell Derived Exosomes Alleviate Type 2 Diabetes Mellitus by Reversing Peripheral Insulin Resistance and Relieving β-Cell Destruction

JournalACS Nano

ApplicationWB

IF13.903

SpeciesRat

PMID30052036
ErbB1-dependent signalling and vesicular trafficking in primary afferent nociceptors associated with hypersensitivity in neuropathic pain

JournalNeurobiology Of Disease

ApplicationIF

IF5.996

SpeciesRat

PMID32531343