Product Name :Tau (phospho-S404) polyclonal antibody（KU）
Reactivity :Human,Mouse,Rat
Application_all :WB: 1:500~1:1000
Background :Tau, also known as MAPT (microtubule-associated protein tau), MAPTL, MTBT1 or TAU, is a 758 amino acid protein that localizes to the cytoplasm, as well as to the cytoskeleton and the cell membrane, and contains four Tau/MAP repeats. Expressed in neuronal tissue and existing as multiple alternatively spliced isoforms, Tau functions to promote microtubule assembly and stability and is thought to be involved in the maintenance of neuronal polarity. Tau may also link microtubules with neural plasma membrane components and, addition to its role in microtubule stability, is also necessary for cytoskeletal plasticity.
Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :p-Tau (S404) polyclonal antibody detects endogenous levels of Tau only when phosphorylated at Ser721, isoforms Tau-4 phosphorylated at Ser404, and other isoforms phosphorylated at the corresponding Site.
Note :For research use only, not for use in diagnostic procedure.
Pathway :Neuronal and Glial Cell Marker Atlas,Amyloid Plaque and Neurofibrillary Tangle Formation in Alzheimer's Disease,
Alternative Name :Microtubule-associated protein tau; Neurofibrillary tangle protein; Paired helical filament-tau; PHF-tau; MAPT; MAPTL; MTBT1; TAU
Immunogen :Synthetic phosphopeptide derived from human isoforms Tau-4 around the phosphorylation site of Serine 404.
Modification :Phosphorylation
