Product Name :Syk (phospho-Y348) polyclonal antibody
Reactivity :Human,Mouse,Rat
Application_all :IHC: 1:50~1:200
Background :Syk (spleen tyrosine kinase) is a 635 amino acid protein that contains one protein kinase domain and two SH2 domains. One of several members of the protein kinase superfamily, Syk functions as a positive effector of B cell antigen receptor (CD79)-stimulated responses, coupling CD79 with the movement of one calcium ion through one of two phospho-regulated pathways. Via its ability to influence CD79 activity and to control the movement of calicum through the cell, Syk plays an important role in a variety of cellular responses, including differentiation, phagocytosis, proliferation and B cell development. Syk expression is upregulated in T cell lymphoma, suggesting a possible role for Syk in tumorigenesis. Two isoforms of Syk, designated short and long, exist due to alternative splicing events.
Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :p-Syk (Y348) polyclonal antibody detects endogenous levels of Syk protein only when phosphorylated at Tyr348.
Note :For research use only, not for use in diagnostic procedure.
Pathway :Immune Cell Signaling,B cell receptor signaling,
Alternative Name :Tyrosine-protein kinase SYK; Spleen tyrosine kinase; p72-Syk; SYK
Immunogen :Synthetic phosphopeptide derived from human Syk around the phosphorylation site of Tyrosine 348.
Modification :Phosphorylation
