产品类别

联系我们

电话:025-68037686

地址:江苏生命科技创新园F6幢1层

订购:nanjing03@biogot.com

服务:biorase01@biogot.com

合作:lvyun@biogot.com

支持:may@biogot.com

Stat5a (phospho-S780) polyclonal antibody（KU）

货号: BS4184

价格：￥ 1350

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

抗体定制服务咨询

说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS4184

Product Name :Stat5a (phospho-S780) polyclonal antibody（KU）

Swiss-Prot :P42229

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC IP

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200 IP: 1:50~1:200

Background :Stat 5a protein is a transcription factor activated by hormone and cytokines. Two highly related, but distinct Stat 5 genes (Stat 5a and Stat 5b) were identified in mouse. The amino acid sequences of Stat 5a and Stat 5b show 96% sequence similarity, and both proteins are co expressed in most tissues of both virgin and lactating mice. However, differential accumulation of Stat 5a and Stat 5b mRNA has been reported for both muscle and mammary tissue. Stat 5a is critically involved in a variety of physiological functions, including reproduction, lactation, immune function and somatic growth.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :p-Stat5a (S780) pAbdetects endogenous levels of Stat5a protein only when phosphorylated at Ser780

BiowMW :~ 91 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Immune Cell Signaling,Jak Stat ：IL-6 Receptor Signaling,T cell receptor signaling,

Alternative Name :Signal transducer and activator of transcription 5A; STAT5A; STAT5

Immunogen :Synthetic phosphopeptide derived from human Stat5a around the phosphorylation site of Serine 780.

Conjugate :Unconjugated

Modification :Phosphorylation

Western blot (WB) analysis of p-Stat5a (S780) pAb at 1:500 dilution Lane1:HepG2 whole cell lysate(40ug) Lane2:MCF-7 whole cell lysate(40ug) Lane3:L02 whole cell lysate(40ug)

Immunohistochemistry (IHC) analyzes of p-STAT5a (S780) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.

Oncostatin M receptor β deficiency attenuates atherogenesis by inhibiting JAK2/STAT3 signaling in macrophages

JournalJournal Of Lipid Research

ApplicationWB

IF4.483

SpeciesMouse

PMID28258089
P38γ modulates the lipid metabolism in non-alcoholic fatty liver disease by regulating the JAK–STAT signaling pathway

JournalFASEB JOURNAL

ApplicationWB

IF5.834

SpeciesMouse

PMID36527390