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SHP-2 (phospho-Y542) polyclonal antibody（KU）

货号: BS4170

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :BS4170

Product Name :SHP-2 (phospho-Y542) polyclonal antibody（KU）

Swiss-Prot :Q06124

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200

Background :Several groups have independently identified a non-transmembrane PTP, designated SH-PTP1 (also known as PTP1C, HCP and SHP), which is primarily expressed in hematopoietic cells and characterized by the presence of two SH2 domains N-terminal to the PTP domain. SH2 domains generally mediate the association of regulatory molecules with specific phosphotyrosine-containing sites on autophosphorylated receptors, thereby controlling the initial interaction of receptors with these substrates. A second and much more widely expressed PTP with SH2 domains, SH-PTP2 (also designated PTP1D and Syp), has been identified. Strong sequence similarity between SH-PTP2 and the Drosophila gene corkscrew (CSW) and their similar patterns of expression suggest that SH-PTP2 is the human corkscrew homolog.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :p-SHP-2 (Y542) polyclonal antibody detects endogenous levels of SHP-2 protein only when phosphorylated at Tyr542.

BiowMW :~ 70 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Immune Cell Signaling,Insulin &Glucose Signaling,B cell receptor signaling,

Alternative Name :Tyrosine-protein phosphatase non-receptor type 11; Protein-tyrosine phosphatase 1D; PTP-1D; Protein-tyrosine phosphatase 2C; PTP-2C; SH-PTP2; SHP-2; Shp2; SH-PTP3; PTPN11; PTP2C; SHPTP2

Immunogen :Synthetic phosphopeptide derived from human SHP-2 around the phosphorylation site of Tyrosine 542.

Conjugate :Unconjugated

Modification :Phosphorylation

Western blot (WB) analysis of p-SHP-2 (Y542) polyclonal antibody at 1:500 dilution Lane1:A549 whole cell lysate Lane2:Raw264.7 whole cell lysate Lane3:H9C2 whole cell lysate

Immunohistochemistry (IHC) analyzes of p-SHP-2 (Y542) pAb in paraffin-embedded human breast cancer tissue.

Shp2 Plays an Important Role in Acute Cigarette Smoke-Mediated Lung Inflammation

JournalJournal Of Immunology

ApplicationWB

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SpeciesHuman

PMID22891281
SHPS‐1 deficiency induces robust neuroprotection against experimental stroke by attenuating oxidative stress

JournalJournal Of Neurochemistry

ApplicationWB

IF4.066

SpeciesMouse

PMID22671569
Bacteroides fragilis alleviates the symptoms of lupus nephritis via regulating CD1d and CD86 expressions in B cells

JournalEuropean Journal Of Pharmacology

ApplicationWB

IF3.263

SpeciesMouse

PMID32721450