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RGMA Rabbit monoclonal antibody（KU）

货号: BS41370

价格：￥ 1200

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS41370

Product Name :RGMA Rabbit monoclonal antibody（KU）

Swiss-Prot :Q96B86

Host :Rabbit

Reactivity :Human Mouse Rat

Applications :WB ICC/IF

Application_all :WB 1:500~1:2000 ICC/IF 1:50~1:200

Background :Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

Purification&Purity :Affinity-chromatography

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :RGMA Antibody detects endogenous levels of total RGMA

BiowMW :37kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Repulsive guidance molecule A; RGM; RGM domain family member A; RGMA;

Immunogen :A synthesized peptide derived from human RGMA

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of RGMA expression in Hela cell lysate.

免疫沉淀（IP）