Product Name :NFκB-p105/p50 (phospho-S337) polyclonal antibody
Reactivity :Human,Mouse,Rat
Application_all :IHC: 1:50~1:200
Background :Proteins encoded by the v-Rel viral oncogene and its cellular homolog, c-Rel, are members of a family of transcription factors that include the two subunits of the transcription factor NFκB (p50 and p65) and the Drosophila maternal morphogen, dorsal. The DNA binding activity of NFκB is activated and NFκB is subsequently transported from the cytoplasm to the nucleus in cells exposed to mitogens or growth factors. cDNAs encoding precursors for two distinct proteins of the same size have been described, designated p105 and p100. The p105 precursor contains p50 at its N-terminus and a C-terminal region that when expressed as a separate molecule, designated pdI, binds to p50 and regulates its activity.
Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :p-NFκB-p105/p50 (S337) polyclonal antibody detects endogenous levels of NFκB-p105/p50 only when phosphorylated at Ser337.
Note :For research use only, not for use in diagnostic procedure.
Pathway :NF-kB Signaling,STING Signaling,Inhibition of Apoptosis,
Alternative Name :Nuclear factor NF-kappa-B p105 subunit; DNA-binding factor KBF1; EBP-1; Nuclear factor of kappa light; polypeptide gene enhancer in B-cells 1; NFKB1; NFkB p105; Nuclear factor NF-kappa-B p50 subunit; NFkB p50;
Immunogen :Synthetic phosphopeptide derived from human NFkB-p105 around the phosphorylation site of Serine 337.
Modification :Phosphorylation
