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Myc (phospho-S62) polyclonal antibody

货号: BS4126

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :BS4126

Product Name :Myc (phospho-S62) polyclonal antibody

Swiss-Prot :P01106

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200

Background :c-Myc-, N-Myc- and L-Myc-encoded proteins function in cell proliferation, differentiation and neoplastic disease. Myc proteins are nuclear proteins with relatively short half lives. Amplification of the c-Myc gene has been found in several types of human tumors including lung, breast and colon carcinomas, while the N-Myc gene has been found amplified in neuroblastomas. The presence of three sequence motifs in the c-Myc COOH terminus, including the leucine zipper, the helix-loop-helix and a basic region provided initial evidence for a sequence-specific binding function.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :p-Myc (S62) polyclonal antibody detects endogenous levels of proto-oncogene c-Myc protein only when phosphorylated at Ser62.

BiowMW :~ 49, 57, 65 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Warburg Effect,Signaling Pathways Activating p38 MAP KinaseCell Cycle Control G1 S Checkpoint,Glutamine Metabolism,

Alternative Name :Myc proto-oncogene protein; Class E basic helix-loop-helix protein 39; bHLHe39; Proto-oncogene c-Myc; Transcription factor p64; MYC; BHLHE39

Immunogen :Synthetic phosphopeptide derived from human Myc around the phosphorylation site of Serine 62.

Conjugate :Unconjugated

Modification :Phosphorylation

Western blot (WB) analysis of p-c-Myc (S62) polyclonal antibody at 1:500 dilution Lane1:Hela cell lysate treated with UV Lane2:NIH-3T3 cell lysate treated with Forskolin Lane3:PC12 cell lysate treated with UV

Immunohistochemistry (IHC) analyzes of p-Myc (S62) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.

Combination chemotherapy with Zyflamend reduced the acquired resistance of bladder cancer cells to cisplatin through inhibiting NFκB signaling pathway

JournalOncoTargets and Therapy

ApplicationWB

IF3.046

SpeciesHuman

PMID30104883
Structure-Guided Discovery and Preclinical Assessment of Novel (Thiophen-3-yl)aminopyrimidine Derivatives as Potent ERK1/2 Inhibitors

JournalJOURNAL OF MEDICINAL CHEMISTRY

ApplicationWB

IF7.3

SpeciesHuman

PMID38613499