Product Name :MEF-2 (phospho-T312) polyclonal antibody
Reactivity :Human,Mouse,Rat
Application_all :IHC: 1:50~1:200
IP: 1:10~1:100
Background :The myocyte enhancer factor-2 (MEF-2) family of transcription factors associated with co-repessors or co-activators to regulate development and function of T cells, neuronal cells and muscle cells. Four family members arise from alternatively spliced transcripts, termed MEF-2A, -2B, -2C and -2D. These members bind as homo- and heterodimers to the MEF-2 site in the promoter region of affected genes. Differential regulation in the expression of the four transcripts implies functional distinction for each during embryogenesis and development. The process of differentiation from mesodermal precursor cells to myoblasts has led to the discovery of a variety of tissue-specific factors that regulate muscle gene expression.
Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :p-MEF-2 (T312) polyclonal antibody detects endogenous levels of MEF-2 protein only when phosphorylated at Thr312
Note :For research use only, not for use in diagnostic procedure.
Pathway :Signaling Pathways Activating p38 MAP Kinase,Examples of Crosstalk Between Post-translational Modifications,
Alternative Name :Myocyte-specific enhancer factor 2A; Serum response factor-like protein 1; MEF2A; MEF2
Immunogen :Synthetic phosphopeptide derived from human MEF-2 around the phosphorylation site of Threonine 312.
Modification :Phosphorylation
