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LIMK1 (phospho-T508) polyclonal antibody

货号: BS4115

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :BS4115

Product Name :LIMK1 (phospho-T508) polyclonal antibody

Swiss-Prot :P53667

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC IF

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200

Background :Proteins containing LIM motifs are typically involved in cell fate determination and growth control. A family of proteins designated LIM kinases, including LIMK-1 and LIMK-2, has been identified. LIMK-1 has been shown to regulate the stabilization of F-Actin structures and cofilin activity, indicating that LIMK-1 plays a role in a signaling pathway involved in the regulation of cell motility and morphogenesis. LIMK-1 inhibits neuronal differentiation of PC12 cells, and is thought to act by interfering with events downstream of MAPK activation. Expression patterns of LIMK-1 and LIMK-2 suggest that these proteins may have different functions during development. A truncated form of LIMK-2 has been identified in adult testis that is thought to arise from an alternative initiation exon.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :p-LIMK1 (T508) polyclonal antibody detects endogenous levels of LIMK1 protein only when phosphorylated at Thr508.

BiowMW :~ 72 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Regulation of Actin Dynamics,Regulation of Microtubule Dynamics,

Alternative Name :LIM domain kinase 1; LIMK-1; LIMK1; LIMK

Immunogen :Synthetic phosphopeptide derived from human LIMK1 around the phosphorylation site of Threonine 508.

Conjugate :Unconjugated

Modification :Phosphorylation

Western blot (WB) analysis of p-LIMK1 (T508) polyclonal antibody in extracts from PC12 cells.

Immunohistochemistry (IHC) analyzes of p-LIMK1 (T508) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.

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