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JAK1 (phospho-Y1022) polyclonal antibody

货号: BS4108

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :BS4108

Product Name :JAK1 (phospho-Y1022) polyclonal antibody

Swiss-Prot :P23458

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200

Background :JAK1 (Janus kinase 1) belongs to the family of non-receptor Janus tyrosine kinases, which regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Immunological stimuli, such as interferons and cytokines, induce recruitment of Stat transcription factors to cytokine receptor-associated JAK1. JAK1 then phosphorylates proximal Stat factors, which subsequently dimerize, translocate to the nucleus and bind to cis elements upstream of target gene promoters to regulate transcription. Upon ligand binding, JAK1 undergoes tyrosine phosphorylation and catalytic activation in an interdependent manner. Phosphorylation of tyrosine residues at positions 1022 and 1023 is believed to function in the activation of catalytic events.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :p-JAK1 (Y1022) polyclonal antibody detects endogenous levels of JAK1 protein only when phosphorylated at Tyr1022.

BiowMW :~ 125 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Jak Stat ：IL-6 Receptor Signaling,Inhibition of Apoptosis,

Alternative Name :Tyrosine-protein kinase JAK1; Janus kinase 1; JAK-1; JAK1; JAK1A; JAK1B

Immunogen :Synthetic phosphopeptide derived from human JAK1 around the phosphorylation site of Tyrosine 1022.

Conjugate :Unconjugated

Modification :Phosphorylation

Immunohistochemistry (IHC) analyzes of p-JAK1 (Y1022) pAb in paraffin-embedded human breast cancer tissue at 1:50.

Neuronal MHC Class I Expression Is Regulated by Activity Driven Calcium Signaling

JournalPLoS One

ApplicationWB

IF2.776

SpeciesMouse

PMID26263390
Type II cGMP‑dependent protein kinase inhibits EGF‑induced JAK/STAT signaling in gastric cancer cells

JournalMolecular Medicine Reports

ApplicationWB

IF2.1

SpeciesHuman

PMID27357186
Andrographolide Inhibition of Th17-Regulated Cytokines and JAK1/STAT3 Signaling in OVA-Stimulated Asthma in Mice

JournalEvidence-based Complementary and Alternative Medicine

ApplicationWB

IF2.629

SpeciesMouse

PMID34194525
Dapagliflozin protects against nonalcoholic steatohepatitis in db/db mice.

JournalFrontiers in Pharmacology

ApplicationWB

IF5.988

SpeciesMouse

PMID36059948
Transglutaminase 2 regulates endothelial cell calcification via IL-6-mediated autophagy

Journal10.3389/fphar.2024.1393534

ApplicationWB

IF4.4

SpeciesHuman

PMID39654623