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Cdc6 (phospho-S54) polyclonal antibody

货号: BS4036

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :BS4036

Product Name :Cdc6 (phospho-S54) polyclonal antibody

Swiss-Prot :Q99741

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200

Background :Cell cycle events are regulated by the sequential activation and deactivation of cyclin dependent kinases (Cdks) and by the proteolysis of cyclins. The cell division cycle (Cdc) genes are required at various points in the cell cycle. Cdc25A, Cdc25B and Cdc25C protein tyrosine phosphatases function as mitotic activators by dephosphorylating Cdc2 p34 on regulatory tyrosine residues. Cdc6 is the human homolog of Saccharomyces cerevisiae Cdc6, which is involved in the initiation of DNA replication. Cdc37 appears to facilitate Cdk4/cyclin D1 complex formation and has been shown to form a stable complex with HSP 90.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :p-Cdc6 (S54) polyclonal antibody detects endogenous levels of Cdc6 only when phosphorylated at Ser54.

BiowMW :~ 62 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Cell division control protein 6 homolog; CDC6-related protein; Cdc18-related protein; HsCdc18; p62(cdc6); HsCDC6; CDC6; CDC18L; p62 Cdc6

Immunogen :Synthetic phosphopeptide derived from human Cdc6 around the phosphorylation site of Serine 54.

Conjugate :Unconjugated

Modification :Phosphorylation

Western blot (WB) analysis of p-Cdc6 (S54) polyclonal antibody at 1:500 dilution Lane1:Hela cell lysate treated with serum starvation Lane2:Raw264.7 cell lysate treated with serum starvation Lane3:H9C2 cell lysate treated with serum starvation

Immunohistochemistry (IHC) analysis of p-Cdc6 (S54) pAb in paraffin-embedded human lung carcinoma tissue.

FOXM1 Promotes Malignant Proliferation of Esophageal Squamous Cell Carcinoma Through Transcriptional Activating CDC6

JournalDNA AND CELL BIOLOGY

ApplicationWB

IF3.311

SpeciesHuman

PMID35639418