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Phospho-Tau (S396) Rabbit monoclonal antibody（KU）

货号: BS40207

价格：￥ 1200

货期：现货（1-2个工作日）

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详细信息检测数据实验指南文献

No. :BS40207

Product Name :Phospho-Tau (S396) Rabbit monoclonal antibody（KU）

Swiss-Prot :P10636

Host :Rabbit

Reactivity :Human Mouse Rat

Applications :WB IHC

Application_all :WB 1:10000~1:20000 IHC1:100~1:500

Background :Tau is a heterogeneous microtubule-associated protein that promotes and stabilizes microtubule assembly, especially in axons. Six isoforms with different amino-terminal inserts and different numbers of tandem repeats near the carboxy-terminus have been identified, and tau is hyperphosphorylated at approximately 25 sites by ERK, GSK-3 and CDK5 . Phosphorylation decreases the ability of tau to bind to microtubules. Neurofibrillary tangles are a major hallmark of Alzheimer's disease and these tangles are bundles of paired helical filaments composed of hyperphosphorylated tau.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

Purification&Purity :Affinity-chromatography

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Phospho-Tau (S396) Antibody detects endogenous levels of Phospho-Tau (S396)

BiowMW :50-80kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :MAPT; Microtubule-associated protein tau; MTBT1; Neurofibrillary tangle protein; Paired helical filament-tau; PHF-tau;

Immunogen :A synthesized peptide derived from human Phospho-Tau (S396)

Conjugate :Unconjugated

Modification :Phosphorylated

Western blot analysis of Phospho-Tau (S396) expression in (1) SH-SY5Y cell lysate treated with AP; (2) SH-SY5Y cell lysate.

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