产品类别

联系我们

电话:025-68037686

地址:江苏生命科技创新园F6幢1层

订购:nanjing03@biogot.com

服务:biorase01@biogot.com

合作:lvyun@biogot.com

支持:may@biogot.com

ZNF706 polyclonal antibody

货号: BS3984

价格：￥ 1140

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

抗体定制服务咨询

说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS3984

Product Name :ZNF706 polyclonal antibody

Swiss-Prot :Q9Y5V0

Host :Rabbit

Reactivity :Human,Rat,Mouse

Applications :WB, IHC, IF, IP

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200 IP: 1:50~1:100

Background :Zinc Finger domains account for 5% of all human proteins and interact with various substrates, such as lipids, DNA, RNA, and post-translational modifications. In addition, zinc finger proteins (ZNFs) are involved in transcriptional regulation, signal transduction, and other cellular processes. Zinc finger protein 706 (ZNF706), encoded by a gene located at chromosome 8q22.3, is a member of the C2H2-type zinc finger transcription factor family, the most abundant transcription factor family encoded by the human genome. And according to the structural analysis of ZNF706, it was definitely predicted to physically bind to DNA through the C-terminal zinc finger domain. In previous studies, it was reported that the expression of ZNF706 is upregulated in gastric cancer and laryngeal cancer. And ZNF706 may be a biomarker for the early diagnosis of rheumatoid arthritis. ZNF706 is a potential oncogene in liver cancer and functions as a ferroptosis regulator by modulating SLC7A11 expression, constituting a potential therapeutic target for HCC.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :ZNF706 polyclonal antibody detects endogenous levels of ZNF706 protein.

BiowMW :~ 13 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Zinc finger protein 706; ZNF706; HSPC038; PNAS-113

Immunogen :Synthetic peptide, corresponding to Human ZNF706.

Conjugate :Unconjugated

Modification :Unmodified

Western blot (WB) analysis of ZNF706 polyclonal antibody at 1:500 dilution Lane1:PC3 whole cell lysate(30ug) Lane2:MCF-7 whole cell lysate(30ug) Lane3:A431 whole cell lysate(30ug) Lane4:BV2 whole cell lysate(30ug) Lane5:PMVEC whole cell lysate(30ug) Lane6:The Liver tissue lysate of Mouse(30ug)

Immunohistochemistry (IHC) analyzes of ZNF706 pAb in paraffin-embedded mouse spleen tissue at 1:100.

Immunofluorescence analysis of MCF-7 cells using ZNF706 pAb at dilution of 1:50 . Blue: DAPI for nuclear staining.

Immunoprecipitation of MCF-7 cell lysates using ZNF706 pAb (Magnetic agrose Bead Conjugate) #BD0082(lane 2 and lane 3) and Nonspecific IgG Control (Magnetic agrose Bead Conjugate)#BD0082 (lane 4) .Lane 1 is 30% input. The western blot was probed using ZNF706 pAb.“↑”(supernatant); “↓”(deposition)