产品类别

联系我们

电话:025-68037686

地址:江苏生命科技创新园F6幢1层

订购:nanjing03@biogot.com

服务:biorase01@biogot.com

合作:lvyun@biogot.com

支持:may@biogot.com

VCP (A346) polyclonal antibody

货号: BS3773

价格：￥ 1140

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

抗体定制服务咨询

说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS3773

Product Name :VCP (A346) polyclonal antibody

Swiss-Prot :P55072

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200

Background :Valosin-containing protein (VCP or p97) belongs to the AAA (ATPase associated activities) family and acts as a molecular chaperone to a wide variety of cellular activities. Some of these activities include the alteration of both nuclear and mitotic golgi membranes, ubiquitin-proteasome dependent protein degradation, regulation of the NF-kappa b pathway, and extraction of membrane proteins. VCP has been shown to contain a substrate binding domain (N) and two conserved ATPase domains (D1 and D2). The three dimensional structure of VCP resembles that of a cylinder with the D1 and D2 stacked upon one another in a homo-hexameric ring formation. VCP is involved in the formation of neuronal inclusion bodies in neurodegenerative disease such as Parkinson's Disease.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :VCP (A346) polyclonal antibody detects endogenous levels of VCP protein.

BiowMW :~ 88 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :15S Mg(2+) ATPase p97 subunit; ATPase p97; IBMPFD; MGC131997; MGC148092; MGC8560; TER ATPase; TERA; p97; transitional endoplasmic reticulum ATPase; valosin-containing protein; yeast Cdc48p homolog

Immunogen :Synthetic peptide, corresponding to amino acids 320-370 of Human VCP.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of VCP (A346) polyclonal antibody in extracts from Hela cells and Raw264.7 cells treated with LPS.

Immunohistochemistry (IHC) analyzes of VCP (A346) pAb in paraffin-embedded human brain tissue.

Differential proteome and gene expression reveal response to carbon ion irradiation in pubertal mice testes

JournalToxicology Letters

ApplicationWB

IF3.499

SpeciesMouse

PMID24440814