产品类别

联系我们

电话:025-68037686

地址:江苏生命科技创新园F6幢1层

订购:nanjing03@biogot.com

服务:biorase01@biogot.com

合作:lvyun@biogot.com

支持:may@biogot.com

MAPKAPK-2 (N266) polyclonal antibody

货号: BS3766

价格：￥ 1140

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

抗体定制服务咨询

说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS3766

Product Name :MAPKAPK-2 (N266) polyclonal antibody

Swiss-Prot :P49137

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200

Background :MAP kinase activated protein kinase 2 (MAPKAP Kinase 2), also known as p45 hsp27 kinase, is a 45-54 kDa serine/threonine protein kinase that contains a proline rich sequence and two putative SH3 binding sites. MAPKAP Kinase 2 is activated in response to stress, IL1 and TNF, possibly catalyzed by p38/Hog dependent phosphorylation. One of the major substrates of MAPKAP Kinase 2 is hsp27, which stimulates actin polymerization in order to facilitate recovery from destruction of cytoskeleton during cellular stresses. MAPKAP2 is implicated in several disorders including ischemic brain injury and heart failure and has been shown to be important in regulating stress resistance and the production of TNF alpha.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :MAPKAPK-2 (N266) polyclonal antibody detects endogenous levels of MAPKAPK-2 protein.

BiowMW :~ 46 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Regulation of Microtubule Dynamics,Signaling Pathways Activating p38 MAP KinaseMAPK Erk in Growth and Differentiation Pathway,

Alternative Name :MAPKAP Kinase 2; MAPK-activated protein kinase 2; MAPKAP kinase 2; MAPKAPK-2; MK2; EC 2.7.11.1; MAPKAPK2

Immunogen :Synthetic peptide, corresponding to amino acids 250-300 of Human MAPKAPK-2.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of MAPKAPK-2 (N266) polyclonal antibody at 1:500 dilution Lane1:SGC7901 whole cell lysate(40ug) Lane2:HepG2 whole cell lysate(40ug) Lane3:The Heart tissue lysate of Mouse(40ug) Lane4:H9C2 whole cell lysate(40ug)

Immunohistochemistry (IHC) analyzes of MAPKAPK-2 (N266) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.

Roles of Kruppel-associated Box (KRAB)-associated Co-repressor KAP1 Ser-473 Phosphorylation in DNA Damage Response

JournalJournal Of Biological Chemistry

ApplicationIF

IF4.238

SpeciesHuman

PMID22496453