Product Name :ZIP-kinase (K261) polyclonal antibody
Reactivity :Human,Mouse,Rat
Application_all :IHC: 1:50~1:200
Background :Apoptosis is mediated by death domain containing adapter molecules and a caspase family of proteases. Certainserine/threonine protein kinases, such as ASK1 and RIP, are mediators of apoptosis. A novel serine/threonine kinase that mediates apoptosis was recently identified and designated ZIP kinase. ZIP kinase contains an N terminal kinase domain and a C terminal leucine zipper structure and binds to ATF4 that is a member of ATF/CREBfamily. ZIP kinase has high sequence homology to DAP kinase (death associated protein kinase), which is a mediator of apoptosis induced by gamma interferon. Overexpression of ZIP kinase induces apoptosis. ZIP and DAP kinases represent a novel kinase family, which mediates apoptosis through their catalytic activities. The messenger RNA was ubiquitously expressed in various tissues.
Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :ZIP-kinase (K261) polyclonal antibody detects endogenous levels of ZIP-kinase protein.
Note :For research use only, not for use in diagnostic procedure.
Pathway :Epigenetic Writers and Erasers of Histone H3,
Alternative Name :ZIPK; ZIP kinase; ZIP; Dlk; Death associated protein kinase 3; Death associated kinase 3; Dapk3; Dapk 3; DAP like kinase; DAP kinase 3
Immunogen :Synthetic peptide, corresponding to amino acids 231-280 of Human ZIP-kinase.
Modification :Unmodification
