Product Name :MAPKAPK-2 (N218) polyclonal antibody
Reactivity :Human,Mouse,Rat
Application_all :WB: 1:500~1:1000
IHC: 1:50~1:200
Background :MAP kinase activated protein kinase 2 (MAPKAP Kinase 2), also known as p45 hsp27 kinase, is a 45-54 kDa serine/threonine protein kinase that contains a proline rich sequence and two putative SH3 binding sites. MAPKAP Kinase 2 is activated in response to stress, IL1 and TNF, possibly catalyzed by p38/Hog dependent phosphorylation. One of the major substrates of MAPKAP Kinase 2 is hsp27, which stimulates actin polymerization in order to facilitate recovery from destruction of cytoskeleton during cellular stresses. MAPKAP2 is implicated in several disorders including ischemic brain injury and heart failure and has been shown to be important in regulating stress resistance and the production of TNF alpha.
Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :MAPKAPK-2 (N218) polyclonal antibody detects endogenous levels of MAPKAPK-2 protein.
Note :For research use only, not for use in diagnostic procedure.
Pathway :Regulation of Microtubule Dynamics,Signaling Pathways Activating p38 MAP KinaseMAPK Erk in Growth and Differentiation Pathway,
Alternative Name :MAPKAP Kinase 2; MAPK-activated protein kinase 2; MAPKAP kinase 2; MAPKAPK-2; MK2; EC 2.7.11.1; MAPKAPK2
Immunogen :Synthetic peptide, corresponding to amino acids 200-250 of Human MAPKAPK-2.
Modification :Unmodification
