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TYK2 (V1048) polyclonal antibody（KU）

货号: BS3713

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS3713

Product Name :TYK2 (V1048) polyclonal antibody（KU）

Swiss-Prot :P29597

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IF

Application_all :WB: 1:500~1:1000 IF: 1:50~1:200

Background :Tyk 2 belongs to the family of non-receptor janus tyrosine kinases, which regulate a spectrum of cellular functions occurring downstream of activated cytokine receptors in the lympho-hematopoietic system. Immunological stimuli, such as interferons and cytokines, recruit STAT transcription factors to the cytokine receptor where Tyk 2 is associated. Tyk 2 then phosphorylates proximal STAT factors, which subsequently dimerize, translocate to the nucleus, and bind to cis elements upstream of target gene promoters to regulating transcription. The canonical JAK-STAT pathway is integral to maintaining a normal immune system by stimulating proliferation, differentiation, survival, and host resistance to pathogens. Cytokine induced pro-inflammatory responses are attractive targets for anti-inflammatory therapies, specifically at the level of Jak-STAT signaling.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Tyk 2 (V1048) polyclonal antibody detects endogenous levels of Tyk 2 protein.

BiowMW :~ 120 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Non-receptor tyrosine-protein kinase TYK2

Immunogen :Synthetic peptide, corresponding to Human TYK2.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of TYK2 (V1048) polyclonal antibody at 1:500 dilution Lane1:PC3 whole cell lysate(40ug) Lane2:HEK293T whole cell lysate(40ug) Lane3:A549 whole cell lysate(40ug) Lane4:MCF-7 whole cell lysate(40ug) Lane5:PC12 whole cell lysate(40ug)

Immunofluorescence analysis of PC3 cells using TYK2 (V1048) antibody at dilution of 1:50.