Product Name :PKC β (N655) polyclonal antibody
Reactivity :Human,Mouse,Rat
Application_all :WB: 1:500~1:1000
IHC: 1:50~1:200
Background :PKCs were originally identified as serine/threonine protein kinases whose activity was dependent on calcium and phospholipids. Diacylglycerols (DAG) and tumor promoting phorbol esters bind to and activate PKC. PKCs can be subdivided into at least two major classes including conventional (c) PKC isoforms (α, βI, βII and γ) and novel (n) PKC isoforms (δ, ε, ζ, η and θ). Patterns of expression for each PKC isoform differs among tissues and PKC family members exhibit clear differences in their cofactor dependencies. For instance, the kinase activities of nPKC δ and ε are independent of Ca2+. On the other hand, nPKC δ and ε, as well as all of the cPKC members, possess phorbol ester-binding activities and kinase activities.
Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :PKC β (N655) polyclonal antibody detects endogenous levels of PKC β protein.
Note :For research use only, not for use in diagnostic procedure.
Pathway :Phospholipase Signaling,Inhibition of Apoptosis,G Protein-coupled Receptors Signaling to MAPK Erk,Mitochondrial Control of Apoptosis,
Alternative Name :Protein kinase C beta type; PKC-B; PKC-beta; PKCB; PRKCB1; PRKCB
Immunogen :Synthetic peptide, corresponding to amino acids 621-670 of Human PKC β.
Modification :Unmodification
