Product Name :PAH (R400) polyclonal antibody
Reactivity :Human,Mouse,Rat
Application_all :IHC:1:50~1:200
Background :The PAH gene encodes the enzyme phenylalanine hydroxylase (PAH), which converts phenylalanine to tyrosine and is the rate-limiting enzyme in phenylalanine catabolism. Mammalian PAH is a soluble, homotetrameric protein which is abundantly expressed in human liver. Deficiency of PAH activity results in the autosomal recessive disorder phenylketonuria (PKU), which is characterized by mental retardation unless a low phenylalanine diet is introduced early in life. The PAH gene, which maps to human chromosome 12q23.2, contains all the genetic information necessary to code for functional PAH, demonstrating that a single gene is involved in the classic disease phenotype.
Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :PAH (R400) polyclonal antibody detects endogenous levels of PAH protein.
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :Phenylalanine-4-hydroxylase; PAH; Phe-4-monooxygenase
Immunogen :Synthetic peptide, corresponding to amino acids 371-420 of Human PAH.
Modification :Unmodification
