Product Name :Caspase 4 (E124) polyclonal antibody
Reactivity :Human,Mouse,Rat
Application_all :IHC: 1:50~1:200
Background :A unique family of cysteine proteases has been described that differs in sequence, structure and substrate specificity from any previously described protease family. This family, termed Ced-3/caspase-1, is comprised of caspase-1, caspase-2, caspase-3, caspase-4, caspase-6, caspase-7 (also designated Mch3, ICE-LAP3 or CMH-1), caspase-9 and caspase-10. Ced-3/caspase-1 family members function as key components of the apoptotic machinery and act to destroy specific target proteins which are critical to cellular longevity. Poly(ADP-ribose) polymerase plays an integral role in surveying for DNA mutations and double strand breaks.
Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Caspase-4 (E124) polyclonal antibody detects endogenous levels of Caspase-4 protein.
Note :For research use only, not for use in diagnostic procedure.
Pathway :Inflammasonme Signaling,Necrotic Cell Death,
Alternative Name :Caspase-4; CASP-4; ICE(rel)-II; Protease ICH-2; Protease TX; Caspase-4 subunit 1; CASP4; ICH2; Caspase 4; Caspase4
Immunogen :Synthetic peptide, corresponding to amino acids 100-150 of Human Caspase 4.
Modification :Unmodification
