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TRAF6 (H154) polyclonal antibody（KU）

货号: BS3684

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS3684

Product Name :TRAF6 (H154) polyclonal antibody（KU）

Swiss-Prot :Q9Y4K3

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200

Background :Tumor necrosis factor receptor-associated factor 6 (TRAF6) regulates adaptive immunity, innate immunity and bone metabolism. TRAF6 is a ubiquitin (Ub) ligase that mediates the activation of protein kinases, such as transforming growth factor beta-activated kinase (TAK1) and IκB kinase (IKK), by catalyzing the formation of a unique polyubiquitin chain linked through Lys 63 of Ub. TRAF6 is essential for activating NFκB signaling pathway in response to interleukin-1 and Toll-like receptor ligands. The coiled-coil domain of TRAF6 is essential for its auto-ubiquitination and activating NFκB signaling pathway. TRAF6 interacts with various protein kinases including IRAK1/IRAK, SRC and PKCζ, which provides a link between distinct signaling pathways.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :TRAF6 (H154) polyclonal antibody detects endogenous levels of TRAF6 protein.

BiowMW :~ 58 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Toll-like Receptor signaling,Death Receptor Signaling,

Alternative Name :TNF receptor-associated factor 6; E3 ubiquitin-protein ligase TRAF6; Interleukin-1 signal transducer; RING finger protein 85; TRAF6; RNF85; TRAF 6; TRAF-6;

Immunogen :Synthetic peptide, corresponding to amino acids 122-170 of Human TRAF6.

Conjugate :Unconjugated

Modification :Unmodified

Western blot (WB) analysis of TRAF6 (H154) polyclonal antibody at 1:500 dilution Lane1:MCF-7 cell lysate Lane2:Mouse kidney tissue lysate Lane3:Rat kidney tissue lysate Lane4:HEK293T cell lysate

Immunohistochemistry (IHC) analyzes of TRAF6 (H154) pAb in paraffin-embedded human colon carcinoma tissue at 1:50,showing cytoplasmic and nuclear staining.Negative control (the right)Using PBS instead of primary antibody, secondary antibody is Goat Anti-Rabbit IgG-biotin followed by avidin-peroxidase.

Immunohistochemistry (IHC) analyzes of TRAF6 (H154) pAb in paraffin-embedded human tonsil carcinoma tissue at 1:50,showing cytoplasmic and nuclear staining.Negative control (the right)Using PBS instead of primary antibody, secondary antibody is Goat Anti-Rabbit IgG-biotin followed by avidin-peroxidase.

Synergistic effect of mesenchymal stem cell-derived extracellular vesicle and miR-137 alleviates autism-like behaviors by modulating the NF-κB pathway

JournalJournal of Translational Medicine

ApplicationWB

IF7.4

SpeciesMouse

PMID38741170