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Op18 (A18) polyclonal antibody（KU）

货号: BS3615

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS3615

Product Name :Op18 (A18) polyclonal antibody（KU）

Swiss-Prot :P16949

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC IF

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200

Background :Op18 (for oncoprotein 18, also designated stathmin, prosolin or metablastin) is a conserved, tubulin-associated, intracellular phosphoprotein. Many different phosphorylated forms of Op18 are observed, and it is expressed as two different isoforms. Op18 is considered a critical regulator of microtubulin dynamics and is downregulated by p53. It serves as a transducing protein, via phosphorylation, for a variety of cell signaling pathways and is involved in both mitosis and differentiation. Op18 is present in many cancers, including breast carcinomas, and is highly expressed in acute leukemias of different subtypes.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Op18 (A18) polyclonal antibody detects endogenous levels of Op18 protein.

BiowMW :~ 19 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Regulation of Microtubule Dynamics,

Alternative Name :Stathmin; Leukemia-associated phosphoprotein p18; Metablastin; Oncoprotein 18; Op18; Phosphoprotein p19; pp19; Prosolin; Protein Pr22; pp17; STMN1; C1orf215; LAP18; OP18

Immunogen :Synthetic peptide, corresponding to the N-terminus of Human Op18.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of Op18 (A18) pAb at 1:500 dilution Lane1:Hela whole cell lysate(40ug) Lane2:K562 whole cell lysate(10ug) Lane3:The Brain tissue lysate of Rat(10ug) Lane4:The Brain tissue lysate of Mouse(40ug)

Immunohistochemistry (IHC) analyzes of Op18 (A18) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.

Synchronous detection of miRNAs, their targets and downstream proteins in transferred FFPE sections: Applications in clinical and basic research

JournalMethods

ApplicationIHC

IF3.782

SpeciesHuman,Mouse

PMID22868004