Product Name :mTOR (S2442) polyclonal antibody（KU）
Reactivity :Human,Mouse,Rat
Application_all :WB:1:500~1:1000
IF: 1:50~1:200
IP:1:50~1:200
Background :mTOR, or FKBP12-rapamycin associated protein (FRAP), is one of a family of proteins involved in cell cycle progression, DNA recombination, and DNA damage detection. In rat, it is a 245-kDa protein (symbolized RAFT1) with significant homology to the Saccharomyces cerevisiae protein TOR1 and has been shown to associate with the immunophilin FKBP12 in a rapamycin-dependent fashion. The FKBP12-rapamycin complex is known to inhibit progression through the G1 cell cycle stage by interfering with mitogenic signaling pathways involved in G1 progression in several cell types, as well as in yeast. The binding of FRAP to FKBP12-rapamycin correlated with the ability of these ligands to inhibit cell cycle progression.
Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :mTOR (S2442) polyclonal antibody detects endogenous levels of mTOR protein.
Note :For research use only, not for use in diagnostic procedure.
Pathway :AMPK Signaling Pathway,Tumor Angiogenesis,Autophagy Signaling,ErbB HER Signaling,Jak Stat ：IL-6 Receptor Signaling,Insulin &Glucose Signaling,PI3K AKT signaling,TGFβ Smad signaling,Translational Contral elF4 and p70 S6 Kinase,Warburg Effect,MTOR signaling,
Alternative Name :Serine/threonine-protein kinase mTOR; FK506-binding protein 12-rapamycin complex-associated protein 1; FKBP12-rapamycin complex-associated protein; Mammalian target of rapamycin; mTOR; Mechanistic target of rapamycin; Rapamycin and FKBP12 target 1; Rapamycin target protein 1; MTOR; FRAP; FRAP1; FRAP2; RAFT1; RAPT1
Immunogen :Synthetic peptide, corresponding to Human mTOR.
Modification :Unmodification
