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Cofilin (M1) polyclonal antibody（KU）

货号: BS3579

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS3579

Product Name :Cofilin (M1) polyclonal antibody（KU）

Swiss-Prot :P23528

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC IF

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200

Background :Cofilin is ubiquitously expressed in eukaryotic cells where it binds to Actin, thereby regulating the rapid cycling of Actin assembly and disassembly, essential for cellular viability. Cofilin is a low molecular weight protein that binds to filamentous F-Actin by bridging two longitudinally-associated Actin subunits, changing the F-Actin filament twist. This process is allowed by the dephosphorylation of Cofilin Ser 3 by factors like opsonized zymosan. LIM kinase 1 (LIMK-1), a serine kinase, phosphorylates Cofilin and renders it unable to bind and depolymerize F-Actin.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Cofilin (M1) polyclonal antibody detects endogenous levels of Cofilin protein.

BiowMW :~ 19 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Phosphoinosotode Signaling,Regulation of Actin Dynamics,Tumor Angiogenesis,Regulation of Microtubule Dynamics,B cell receptor signaling,

Alternative Name :Cofilin-1; 18 kDa phosphoprotein; p18; Cofilin; non-muscle isoform; CFL1; CFL

Immunogen :Synthetic peptide, corresponding to the N-terminal of Human Cofilin 1.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of Cofilin (M1) polyclonal antibody at 1:500 dilution Lane1:H9C2 whole cell lysate(40ug) Lane2:AML-12 whole cell lysate(40ug) Lane3:L02 whole cell lysate(40ug) Lane4:A549 whole cell lysate(40ug) Lane5:MCF-7 whole cell lysate(40ug)

Immunohistochemistry (IHC) analyzes of Cofilin (M1) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.

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