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Insulin (F49) polyclonal antibody（KU）

货号: BS3546

价格：￥ 1140

货期：现货（1-2个工作日）

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详细信息检测数据实验指南文献

No. :BS3546

Product Name :Insulin (F49) polyclonal antibody（KU）

Swiss-Prot :P01308

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC

Application_all :WB: 1:500~1:2000 IHC: 1:50~1:200

Background :Insulin is one of the major regulatory hormones of intermediate metabolism throughout the body. The biological actions of this hormone involve integration of carbohydrate, protein, and lipid metabolism. Insulin enhances membrane transport of glucose, amino acids, and certain ions. It also promotes glycogen storage, formation of triglycerides and synthesis of proteins and nucleic acids. Immunocytochemical investigations have localized insulin in the B cells of pancreatic islets of Langerhans. Deficiency of insulin results in diabetes mellitus, one of the leading causes of morbidity and mortality in the general population. Insulin is also present in tumors of B cell origin such as insulinoma.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Insulin (F49) polyclonal antibody detects endogenous levels of Insulin protein.

BiowMW :~ 17 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Insulin &Glucose Signaling,

Alternative Name :Insulin; INS

Immunogen :Synthetic peptide, corresponding to amino acids 11-60 of Human Insulin.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of Insulin (F49) pAb at 1:500 dilution Lane1:The Uterus tissue lysate of Rat(40ug) Lane2:MCF-7 whole cell lysate(40ug) Lane3:PC3 whole cell lysate(40ug) Lane4:Panc1 whole cell lysate(40ug) Lane5:The Pancreas tissue lysate of Mouse(20ug) Lane6:The Pancreas tissue lysate of Rat(20ug)

Immunohistochemistry (IHC) analyzes of Insulin (F49) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.

Human Mesenchymal Stem Cell Derived Exosomes Alleviate Type 2 Diabetes Mellitus by Reversing Peripheral Insulin Resistance and Relieving β-Cell Destruction

JournalACS Nano

ApplicationIF

IF13.903

SpeciesRat

PMID30052036
Chloroquine-induced proinsulin misfolding in the endoplasmic reticulum underlies the attenuation of mature insulin synthesis

Journal10.1096/fj.202401945R

ApplicationWB

IF4.4

SpeciesRat

PMID39620939