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Rock-1 (N311) polyclonal antibody（KU）

货号: BS3537

价格：￥ 1140

货期：现货（1-2个工作日）

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详细信息检测数据实验指南文献

No. :BS3537

Product Name :Rock-1 (N311) polyclonal antibody（KU）

Swiss-Prot :Q13464

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC IF

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200

Background :Rho proteins function as molecular switches that are able to turn cytokinesis on and off. Although little is known about signaling downstream of Rho, a host of putative Rho effector proteins have been described, including rhophilin, Rhotekin, citron and the serine/threonine kinase, protein kinase N. Two additional Rho-activated serine/threonine kinases have been described, designated Rock-1 and Rock-2 (also referred to as Roka) for Rho-associated coil-containing protein kinase. Rock-1 and Rock-2 share a structural similarity with myotonic dystrophy kinase.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Rock-1 (N311) polyclonal antibody detects endogenous levels of Rock-1 protein.

BiowMW :~ 158 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Regulation of Microtubule Dynamics,Adherens Junction signaling,

Alternative Name :Rho-associated protein kinase 1; Renal carcinoma antigen NY-REN-35; Rho-associated, coiled-coil-containing protein kinase 1; Rho-associated, coiled-coil-containing protein kinase I; ROCK-I; p160 ROCK-1; p160ROCK; ROCK1

Immunogen :Synthetic peptide, corresponding to amino acids 280-331 of Human Rock-1.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of Rock-1 (N311) pAb at 1:500 dilution Lane1:HCT116 whole cell lysate(40ug) Lane2:HEK293T whole cell lysate(40ug) Lane3:CT26 whole cell lysate(40ug) Lane4:PMVEC whole cell lysate(40ug)

Immunohistochemistry (IHC) analyzes of Rock-1 (N311) pAb in paraffin-embedded human brain tissue.

Inhibition of the RhoA/Rho-associated, coiled-coil-containing protein kinase-1 pathway is involved in the therapeutic effects of simvastatin on pulmonary arterial hypertension

JournalClinical And Experimental Hypertension

ApplicationIHC

IF1.749

SpeciesRat

PMID29319354