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P-glycoprotein 1 (I583) polyclonal antibody

货号: BS3523

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS3523

Product Name :P-glycoprotein 1 (I583) polyclonal antibody

Swiss-Prot :P08183

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200

Background :The MDR proteins (Mdrs) are members of a highly conserved superfamily of ATP-binding cassette transport proteins. Mdr functions as an energy-dependent efflux pump for structurally diverse agents ranging from ions to peptides. It is implicated in the development of the multiple drug resistance observed in human cancer cells following prolonged chemotherapy. The classic form of MDR is associated with an increase in the Mdr protein, but not all cases of MDR can be attributed to a rise in Mdr levels. Mdr-1 is an apical transmembrane protein that is an integral part of the blood-brain barrier and functions as a drug-transport pump transporting a variety of drugs from the brain back into the blood. In the human population, there are 15 polymorphisms in the Mdr-1 gene.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :P-glycoprotein 1 (I583) polyclonal antibody detects endogenous levels of P-glycoprotein 1 protein.

BiowMW :~ 180 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Multidrug resistance protein 1; ATP-binding cassette sub-family B member 1; P-glycoprotein 1; CD243; ABCB1; MDR1; PGY1; P-gp

Immunogen :Synthetic peptide, corresponding to amino acids 551-600 of Human Mdr-1.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of P-glycoprotein 1 (I583) polyclonal antibody at 1:500 dilution Lane1:L02 whole cell lysate(40ug) Lane2:HCT116 whole cell lysate(40ug) Lane3:C6 whole cell lysate(40ug) Lane4:CT26 whole cell lysate(40ug)

Immunohistochemistry (IHC) analyzes of P-glycoprotein 1 (I583) pAb in paraffin-embedded human colorectal cancer carcinoma tissue at 1:100.

Effect of Glycyrrhiza uralensis against ulcerative colitis through regulating the signaling pathway of FXR/P-gp

JournalAmerican Journal of Translational Research

ApplicationWB

IF4.06

SpeciesMouse

PMID34540046