产品类别

联系我们

电话:025-68037686

地址:江苏生命科技创新园F6幢1层

订购:nanjing03@biogot.com

服务:biorase01@biogot.com

合作:lvyun@biogot.com

支持:may@biogot.com

PAI-1 (N315) polyclonal antibody

货号: BS3503

价格：￥ 1140

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

抗体定制服务咨询

说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS3503

Product Name :PAI-1 (N315) polyclonal antibody

Swiss-Prot :P05121

Host :Rabbit

Reactivity :Human, Mouse, Rat

Applications :WB, IHC

Application_all :WB: 1:500~1:1000IHC: 1:50~1:200

Background :PAI-1 is a secreted protein that belongs to the serine proteinase inhibitor (serpin) superfamily. It inhibits urokinase and tissue plasminogen activators (uPA and tPA) and thus, reduces the conversion of inactive plasminogen to plasmin. PAI-1 regulates fibrinolysis and plays an important role in vessel patency and tissue remodeling. Secreted PAI-1 interacts with the extracellular matrix (ECM) component vitronectin, thereby modulating cell-ECM interactions. PAI-1 is expressed in a variety of tissues with higher expression in liver, vascular endothelial cells, platelets, macrophages, and adipose tissue. Increased levels of PAI-1 are associated with deep vein thrombosis. Defects in PAI-1 cause plasminogen activator inhibitor-1 deficiency (PAI-1D), which is characterized by increased bleeding after injury or surgery. Research studies have shown that high levels of PAI-1 are associated with obesity, aging, insulin resistance, and type 2 diabetes. PAI-1 is transcriptionally regulated by TGF-β and mediates TGF-β-induced inhibition of cell migration and invasion in cancer cells. Studies have also shown PAI-1 to be involved in fibrosis.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide,50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :PAI-1 (N315) polyclonal antibody detects endogenous levels of PAI1 protein.

Note :~ 45 kDa

Pathway :For research use only, not for use in diagnostic procedure.

Alternative Name :PAI1; PLANH1; Plasminogen activator inhibitor 1; PAI; PAI-1; Endothelial plasminogen activator inhibitor; Serpin E1

Immunogen :KLH-conjugated synthetic peptide encompassing a sequence within the center region of human PAI-1.

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of PAI-1 expression in DLD (A), HepG2 (B), PMVEC (C), AML12 (D) whole cell lysates.

Enhancement of DEN-induced liver tumourigenesis in hepatocyte-specific Lass2-knockout mice coincident with upregulation of the TGF-β1-Smad4-PAI-1 axis

JournalOncology Reports

ApplicationWB

IF3.041

SpeciesMouse

PMID24337404
Effect of Chenodeoxycholic Acid on Fibrosis, Inflammation and Oxidative Stress in Kidney in High-Fructose-Fed Wistar Rats

JournalKidney & Blood Pressure Research

ApplicationWB

IF2.687

SpeciesRat

PMID22948014
Effects of astaxanthin on blood coagulation, fibrinolysis and platelet aggregation in hyperlipidemic rats

JournalPharmaceutical Biology

ApplicationWB

IF3.503

SpeciesRat

PMID27951728