Product Name :PI3K p110α (R519) polyclonal antibody
Reactivity :Human,Mouse,Rat
Application_all :IHC: 1:50~1:200
Background :Phosphatidylinositol 3-kinase (PI 3-kinase) is composed of 85 kDa (p85) and 110 kDa (p110) subunits. p85 lacks PI 3-kinase activity and acts as an adapter, coupling p110 to activated protein tyrosine kinase. Two forms of p85 have been described (p85α and p85β), each possessing one SH3 and two SH2 domains. Various p110 isoforms have been identified. p110α and p110β interact with p85α, and p110α has also been shown to interact with p85β in vitro. p110δ expression is restricted to white blood cells. It has been shown to bind p85α and β, but it apparently does not phosphorylate these subunits. p110δ seems to have the capacity to autophosphorylate. p110γ does not interact with the p85 subunits. It has been shown to be activated by α and βγ heterotrimeric G proteins.
Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :PI 3-kinase p110α (R519) polyclonal antibody detects endogenous levels of PI 3-kinase p110α protein.
Note :For research use only, not for use in diagnostic procedure.
Pathway :Phosphoinosotode Signaling,PI3K AKT signaling,Protein Kinase C Signaling,Warburg Effect,Tumor Angiogenesis,Translational Contral elF4 and p70 S6 Kinase,SAPK JNK Signaling Cascades,Inhibition of Apoptosis,Insulin &Glucose Signaling,G Protein-coupled Receptors Signaling to MAPK Erk,Adherens Junction signaling,Mitochondrial Control of Apoptosis,MTOR signaling,
Alternative Name :Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; PI3-kinase subunit alpha; PI3K-alpha; PI3Kalpha; PtdIns-3-kinase subunit alpha; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha; PtdIns-3-kinase subunit p110-alpha; p110alpha; Phosphoinositide-3-kinase catalytic alpha polypeptide; Serine/threonine protein kinase PIK3CA; PIK3CA
Immunogen :Synthetic peptide, corresponding to amino acids 500-550 of Human PI3K p110α.
Modification :Unmodification
