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Synuclein-α (D119) polyclonal antibody

货号: BS3429

价格：￥ 1140

货期：现货（1-2个工作日）

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详细信息检测数据实验指南文献

No. :BS3429

Product Name :Synuclein-α (D119) polyclonal antibody

Swiss-Prot :P37840

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200

Background :The synuclein family members, including α-synuclein (also designated NACP for non-β Amyloid component) and β-synuclein, are predominantly expressed in the brain and are speculated to be involved in synaptic regulation and neuronal plasticity. α-synuclein is localized to neuronal cell bodies and synapses. α-synuclein was first identified as a component of Alzheimer’s disease amyloid plaques. Abnormal platelet function in Alzheimer’s disease has been demonstrated. During megakaryocytic differentiation α-synuclein has been found to be upregulated, while β-synuclein is downregulated, indicating that coordinate expression of synucleins may be important during hematopoetic cell differentiation. A mutant form of α-synuclein has been found in patients with early onset Parkinson’s disease.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Synuclein-α (D119) polyclonal antibody detects endogenous levels of Synuclein-α protein.

BiowMW :~ 18 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Alpha-synuclein; α-synuclein; Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; NACP; SNCA; NACP; PARK1

Immunogen :Synthetic peptide, corresponding to amino acids 100-150 of Human Synuclein-α.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of Synuclein-α (D119) pAb at 1:500 dilution Lane1:SK-OVCAR3 whole cell lysate(40ug) Lane2:HEK293T whole cell lysate(10ug) Lane3:The Brain tissue lysate of Mouse(40ug) Lane4:The Brain tissue lysate of Rat(40ug)

Immunohistochemistry (IHC) analyzes of Synuclein-α (D119) pAb in paraffin-embedded human breast carcinoma tissue at 1:50.

MicroRNA Expression Profiling Screen miR-3557/324-Targeted CaMK/mTOR in the Rat Striatum of Parkinson’s Disease in Regular Aerobic Exercise

JournalBiomed Research International

ApplicationIF

IF3.411

SpeciesRat

PMID31309116
Probiotic Pediococcus pentosaceus ameliorates MPTP-induced oxidative stress via regulating the gut microbiota–gut–brain axis

JournalFrontiers in Cellular and Infection Microbiology

ApplicationIHC, WB

IF6.073

SpeciesMouse

PMID36439235