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Plakophilin 2 (P663) polyclonal antibody（KU）

货号: BS3368

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS3368

Product Name :Plakophilin 2 (P663) polyclonal antibody（KU）

Swiss-Prot :Q99959

Host :Rabbit

Reactivity :Human,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :Plakophilins 1, 2, 3 and 4 (PKP1-4) influence development and participate in linking cadherins to cytoskeletal intermediate filaments. Plakophilins 1-4 contain arm-repeat (armadillo) domains and localize to nuclei and cell desmosomes (cell-cell junctions found in suprabasal layers of stratifying epithelia that undergo mechanical stress). Plakophilin 1 mediates increases in desmosomal protein content, desmosome assembly and regulation of cell migration. Plakophilin 2 is important for desmosome assembly and is an essential morphogenic factor and architectural component of the heart. Plakophilin 4 is a component of desmosomal adhesion plaques that regulates junctional plaque organization and cadherin function.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Plakophilin 2 (P663) polyclonal antibody detects endogenous levels of Plakophilin 2 protein.

BiowMW :~ 97 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Plakophilin-2; PKP2

Immunogen :Synthetic peptide, corresponding to amino acids 634-680 of Human Plakophilin 2.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of Plakophilin 2 (P663) pAb at 1:500 dilution Lane1:SGC7901 whole cell lysate(20ug) Lane2:HCT116 whole cell lysate(20ug) Lane3:The Heart tissue lysate of Rat(20ug)