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ME3 (R576) polyclonal antibody（KU）

货号: BS3339

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS3339

Product Name :ME3 (R576) polyclonal antibody（KU）

Swiss-Prot :Q16798

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200

Background :ME3 (malic enzyme 3), also known as NADP-ME (NADP-dependent malic enzyme, mitochondrial), is a 604 amino acid protein of the mitochondrial matrix that catalyzes the conversion of (S)-malate and NADP+ to pyruvate, carbon dioxide and NADPH. A member of the malic enzymes family, ME3 utilizes manganese and magnesium as cofactors and is expressed in tissues that divide at a low rate. The gene encoding ME3 maps to human chromosome 11, which houses over 1,400 genes and comprises nearly 4% of the human genome. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are associated with defects in genes that maps to chromosome 11.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :ME3 (R576) polyclonal antibody detects endogenous levels of ME3 protein.

BiowMW :~ 67 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :NADP-dependent malic enzyme, mitochondrial; NADP-ME; Malic enzyme 3; ME3

Immunogen :Synthetic peptide, corresponding to amino acids 547-598 of Human ME3.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of ME3 (R576) pAb at 1:500 dilution Lane1:Panc1 whole cell lysate(40ug) Lane2:A549 whole cell lysate(40ug) Lane3:C6 whole cell lysate(40ug) Lane4:The Testis tissue lysate of Mouse(10ug)

Immunohistochemistry (IHC) analyzes of ME3 (R576) pAb in paraffin-embedded human colorectal carcinoma tissue at 1:50.