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CRABP-II (P81) polyclonal antibody（KU）

货号: BS3279

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS3279

Product Name :CRABP-II (P81) polyclonal antibody（KU）

Swiss-Prot :P29373

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :The cellular retinoic acid-binding protein (CRABP)-I and a related isoform CRABP-II are nuclear receptors for retinoic acid (RA), an important regulator of cell growth and differentiation in fetal and adult tissues. These CRABP proteins mediate the downstream effects of RA in distinct ways. CRABP-I negatively regulates the activity of RA by enhancing the production of RAmetabolizing enzymes and increasing the rate at which RA is degraded. CRABP-II enhances the effects of RA by directly interacting with RA receptors (RAR) and, in turn, promoting the formation of RAR-RA complexes and stimulating RA-mediated gene transcription. Both CRABP-I and CRABP-II are expressed in the embryo, and CRABP-I is ubiquitously expressed in various adult tissues. The expression of CRABP-II is elevated in cells that synthesize relatively large amounts of RA, and it is also predominantly expressed in skin, uterus, ovary, and in the choroid plexus.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :CRABP-II (P81) polyclonal antibody detects endogenous levels of CRABP-II cat protein.

BiowMW :~ 16 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Cellular retinoic acid-binding protein 2; Cellular retinoic acid-binding protein II; CRABPII; CRABP II; CRABP2; CRABP 2

Immunogen :Synthetic peptide, corresponding to amino acids 50-100 of Human NCRABP-II.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of CRABP-II (P81) pAb at 1:500 dilution Lane1:PC3 whole cell lysate(40ug) Lane2:C6 whole cell lysate(40ug) Lane3:3T3-L1 whole cell lysate(40ug)