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PKA IIβ reg (T109) polyclonal antibody（KU）

货号: BS3253

价格：￥ 1140

货期：现货（1-2个工作日）

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详细信息检测数据实验指南文献

No. :BS3253

Product Name :PKA IIβ reg (T109) polyclonal antibody（KU）

Swiss-Prot :P31323

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200

Background :The second messenger cyclic AMP (cAMP) mediates diverse cellular responses to external signals such as proliferation, ion transport, regulation of metabolism and gene transcription by activation of the cAMP-dependent protein kinase (cAPK or PKA). Activation of PKA occurs when cAMP binds to the two regulatory subunits of the tetrameric PKA holoenzyme resulting in release of active catalytic subunits. Three catalytic (C) subunits have been identified, designated Cα, Cβ and Cγ, that each represent specific gene products. Cα and Cβ are closely related (93% amino acid sequence similarity), whereas Cγ displays 83% and 79% similarity to Cα and Cβ, respectively.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :PKA IIβ reg (T109) polyclonal antibody detects endogenous levels of PKA IIβ reg protein.

BiowMW :~ 46 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Inhibition of Apoptosis,Mitochondrial Control of Apoptosis,

Alternative Name :PRKAR2B; cAMP-dependent protein kinase type II-beta regulatory subunit

Immunogen :Synthetic peptide, corresponding to amino acids 80-130 of Human PKA IIβ reg.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of PKA IIβ reg (T109) polyclonal antibody at 1:500 dilution Lane1:HEK293T whole cell lysate Lane2:Raw264.7 whole cell lysate Lane3:H9C2 whole cell lysate Lane4:A549 whole cell lysate Lane5:sp2/0 whole cell lysate

Immunohistochemistry (IHC) analyzes of PKA IIβ reg (T109) pAb in paraffin-embedded human cervix carcinoma tissue.

UCH-L1 Inhibition Involved in CREB Dephosphorylation in Hippocampal Slices

JournalJournal Of Molecular Neuroscience

ApplicationWB

IF2.678

SpeciesMouse

PMID
Protective effects of curcumin on desipramine-induced islet β-cell damage via AKAP150/PKA/PP2B complex

JournalACTA PHARMACOLOGICA SINICA

ApplicationWB,IP

IF8.2

SpeciesRat

PMID37845344