Product Name :TRH-R1 (W234) polyclonal antibody
Reactivity :Human,Mouse,Rat
Application_all :IHC: 1:50~1:200
Background :Thyrotrophin-releasing hormone (TRH) is a hypothalamic tripeptide that stimulates, via its receptor in the anterior pituitary gland, the release of thyrotrophin (TSH) and prolactin. The TRH receptors, TRH-R1 and TRH-R2, are G protein-coupled proteins containing seven transmembrane domains and other conserved regions. In rat, two isoforms exist, TRH-R (412) and TRH-R (387), that differ at their carboxy termini. TRH receptors are distributed throughout the central and peripheral nervous systems and are present in a variety of tissues. TRH-R2 displays 50% homology to TRH-R1 and is more restricted to the central nervous system than TRH-R1. Mutation in the TRH receptor gene is associated with isolated central hypothyroidism, a rare disorder characterized by insufficient TSH secretion resulting in low levels of thyroid hormones.
Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :TRH-R1 (W234) polyclonal antibody detects endogenous levels of TRH-R1 protein.
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :Thyrotropin-releasing hormone receptor; TRH-R; Thyroliberin receptor; TRHR
Immunogen :Synthetic peptide, corresponding to amino acids 250-300 of Human TRH-R1.
Modification :Unmodification
