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Paxillin (Q82) polyclonal antibody（KU）

货号: BS3183

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS3183

Product Name :Paxillin (Q82) polyclonal antibody（KU）

Swiss-Prot :P49023

Host :Rabbit

Reactivity :Human,Rat

Applications :WB IHC

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200

Background :Paxillin is a focal adhesion phosphoprotein that is localized to the cytoskeleton. FAK phosphorylates paxillin specifically on Tyr 118 in vitro. However, FAK phosphorylation does not seem to be required for the recruitment of paxillin to cell adhesion sites. Paxillin may play a role in signal transduction, regulation of cell morphology and the recruitment of structural and signaling molecules to focal adhesions. It has been shown that the amount of paxillin is reduced in mitotic cells by proteolytic downregulation and that paxillin is alternatively phosphorylated on serine rather than on tyrosine and serine during mitosis.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Paxillin (Q82) polyclonal antibody detects endogenous levels of Paxillin protein.

BiowMW :~ 65 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Regulation of Actin Dynamics,Tumor Angiogenesis,Contribution of ECM and Cytoskeletal Factors to EMT,

Alternative Name :PXN

Immunogen :Synthetic peptide, corresponding to amino acids 50-100 of Human Paxillin.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of Paxillin (Q82) pAb at 1:500 dilution Lane1:PC12 whole cell lysate(40ug) Lane2:HuT78 whole cell lysate(40ug) Lane3:Panc1 whole cell lysate(40ug) Lane4:A549 whole cell lysate(40ug)