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MRP3 (L1010) polyclonal antibody（KU）

货号: BS3177

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS3177

Product Name :MRP3 (L1010) polyclonal antibody（KU）

Swiss-Prot :O15438

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :MRP1 is an integral membrane protein that contains an MDR-like core, an N-terminal membrane-bound region and a cytoplasmic linker, and it is expressed in various cerebral cells, as well as in lung, testis and peripheral blood. The MRP gene family also includes MRP2, which is alternatively designated cMOAT (for canalicular multispecific organic anion transporter) and MRP3, which are both conjugate export pumps ex- pressed predominantly in hepatocytes. MRP2 localizes exclusively to the apical membrane and is constitutively expressed at a high level in normal liver cells. Conversely, MRP3 localizes to the basolateral membrane where it also me- diates the transport of the organic anion S-(2,4-dinitrophenyl-) glutathione toward the basolateral side of the membrane. MRP3 is normally expressed at comparatively lower levels than MRP2 and increases only when secretion across the apical membrane by MRP2 is impaired.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :MRP3 (L1010) polyclonal antibody detects endogenous levels of MRP3 protein.

BiowMW :~ 260 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Canalicular multispecific organic anion transporter 2; ATP-binding cassette sub-family C member 3; Multi-specific organic anion transporter D; MOAT-D; Multidrug resistance-associated protein 3; ABCC3; CMOAT2; MLP2; MRP3

Immunogen :Synthetic peptide, corresponding to amino acids 981-1030 of Human MRP3.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of MRP3 (L1010) pAb at 1:500 dilution Lane1:A549 whole cell lysate(40ug) Lane2:Hela whole cell lysate(40ug) Lane3:PC12 whole cell lysate(40ug) Lane4:CT26 whole cell lysate(40ug)