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Myotubularin (Y290) polyclonal antibody（KU）

货号: BS2971

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

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No. :BS2971

Product Name :Myotubularin (Y290) polyclonal antibody（KU）

Swiss-Prot :Q13496

Host :Rabbit

Reactivity :Human,Mouse

Applications :IHC

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200

Background :Human MTM1, a 603 amino-acid protein, is mutated in myotubular myopathy. The largely related protein hMTMR2 is found mutated in a recessive form of Charcot-Marie-tooth neuropathy. Myotubularin is primarily a lipid phosphatase that acts on hosphatidylinositol 3-monophosphate and is involved in the regulation of the phosphatidylinositol 3-kinase (PI 3-kinase) pathway and membrane trafficking. Wildtype myotubularin can directly dephosphorylate PI 3-P and PI 4-P in vitro. Thus, it decreases PI 3-P levels by down-regulating PI 3-K activity and by facilitating the degradation of PI 3-P.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Myotubularin (Y290) polyclonal antibody detects endogenous levels of Myotubularin protein.

BiowMW :~ 70 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Myotubularin; MTM1; CG2

Immunogen :Synthetic peptide, corresponding to amino acids 256-3111 of Human Myotubularin.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of Myotubularin (Y290) pAb at 1:2000 dilution Lane1:SGC7901 whole cell lysate(40ug) Lane2:HCT116 whole cell lysate(40ug) Lane3:Panc1 whole cell lysate(40ug)