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SDHA (R600) polyclonal antibody（KU）

货号: BS2847

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS2847

Product Name :SDHA (R600) polyclonal antibody（KU）

Swiss-Prot :P31040

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :In aerobic respiration reactions, succinate dehydrogenase (SDH) catalyzes the oxidation of succinate and ubiquinone to fumarate and ubiquinol. Four subunits comprise the SDH protein complex: a flavochrome subunit (SDHA), an iron-sulfur protein (SDHB), and two membrane-bound subunits (SDHC and SDHD) anchored to the inner mitochondrial membrane. Mutations to these subunits cause mitochondrial dysfunction, corresponding to several distinct disorders. Mutations in the membrane bound components may cause hereditary paraganglioma, while SDHA mutations are associated with juvenile encephalopathy as well as Leigh Syndrome, a severe neurological disorder. Inactivating mutations in SDHB correlate with inherited, but not necessarily sporadic, cases of pheochromocytoma.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :SDHA (R600) polyclonal antibody detects endogenous levels of SDHA protein.

BiowMW :~ 72 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Warburg Effect,Insulin &Glucose Signaling,AMPK Signaling Pathway,

Alternative Name :Succinate dehydrogenase [ubiquinone] flavoprotein subunit; mitochondrial; Flavoprotein subunit of complex II; Fp; SDHA; SDH2; SDHF

Immunogen :Synthetic peptide, corresponding to amino acids 560-610 of Human SDHA.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of SDHA (R600) pAb at 1:2000 dilution Lane1:The Heart tissue lysate of Rat(20ug) Lane2:The Testis tissue lysate of Mouse(40ug) Lane3:HEK293T whole cell lysate(40ug) Lane4:SGC7901 whole cell lysate(40ug) Lane5:HepG2 whole cell lysate(40ug)